Numerous grape varieties are cultivated in France, including both internationally well-known and obscure local varieties. In fact, most of the so-called "international varieties" are of French origin, or became known and spread because of their cultivation in France. Since French appellation rules generally restrict wines from each region, district or appellation to a small number of allowed grape varieties, there are in principle no varieties that are commonly planted throughout all of France.

Most varieties of grape are primarily associated with a certain region, such as Cabernet Sauvignon in Bordeaux and Syrah in Rhône, although there are some varieties that are found in two or more regions, such as Chardonnay in Bourgogne (including Chablis) and Champagne, and Sauvignon Blanc in Loire and Bordeaux. As an example of the rules, although climatic conditions would appear to be favorable, no Cabernet Sauvignon wines are produced in Rhône, Riesling wines in Loire, or Chardonnay wines in Bordeaux. (If such wines were produced, they would have to be declassified to Vin de Pays or French table wine. They would not be allowed to display any appellation name or even region of origin.)